Ethosuximide

Ethosuximide.png
Ethosuximide {{{English}}}
الاسم النظامي (أيوپاك)
الاسم النظامي (أيوپاك)
3-ethyl-3-methyl-pyrrolidine-2,5-dione
المعينات Identifiers
رقم CAS 77-67-8
كود ATC N03AD01
PubChem 3291
بنك العقاقير APRD00318
بيانات كيميائية
الصيغة C7H11NO2 
كتلة جزيئية 141.168 g/mol
بيانات الحركية الدوائية Pharmacokinetic
التوافر الحيوي 93%[1]
الأيض Hepatic (CYP3A4, CYP2E1)
عمر النصف 53 hours
اخراج Renal (20%)
اعتبارات علاجية
فئة السلامة أثناء الحمل

D (Au, U.S.)

الوضع القانوني

℞-only (U.S.)

المسارات Oral

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الاستعمالات

التصريح باستعمال الدواء

عدم التصريح باستعمال الدواء

الجرعات

اتاحة الدواء

نظرية عمل الدواء

التأثيرات الجانبية

الجهاز العصبي المركزى

Common

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Rare

Gastrointestinal















الهامش

Sources

Notes

  1. ^ Patsalos, P. N. (2005). "Properties of Antiepileptic Drugs in the Treatment of Idiopathic Generalized Epilepsies". Epilepsia. 46 (s9): 140–144. doi:10.1111/j.1528-1167.2005.00326.x. PMID 16302888. Unknown parameter |month= ignored (help)
  2. ^ Pharmaceutical Associates, Incorporated (2000). "Ethosuximide Approval Label" (PDF). Label and Approval History. Food and Drug Administration Center for Drug Evaluation and Research. Retrieved 2006-02-05.
  3. ^ "Drugs used in generalized seizures." Katzung, B. Basic and Clinical Pharmacology. 9th Ed. 2003. Lange Medical Books/McGraw-Hill.0071410929.
  4. ^ Andrulonis, P. A. (1980). "Preliminary data on ethosuximide and the Episodic dyscontrol syndrome". American Journal of Psychiatry. 137 (11): 1455–6. PMID 7435689. Unknown parameter |month= ignored (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  5. ^ Coulter DA, Huguenard JR, Prince DA. "Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons." Neurosci Lett. 1989 Mar 13;98(1):74-8. PMID 2710401
  6. ^ "Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons." Annals of Neurology. 1989 Jun;25(6):582-93. PMID 2545161
  7. ^ Coulter DA, Huguenard JR, Prince DA. "Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction." British Journal of Pharmacology. 1990 Aug;100(4):800-6. PMID 2169941
  8. ^ Kostyuk PG, Molokanova EA, Pronchuk NF, Savchenko AN, Verkhratsky AN. "Different action of ethosuximide on low- and high-threshold calcium currents in rat sensory neurons." Neuroscience. 1992 Dec;51(4):755-8. PMID 1336826
  9. ^ Herrington J, Lingle CJ (1992). "Kinetic and pharmacological properties of low voltage-activated Ca2+ current in rat clonal (GH3) pituitary cells". Journal of Neurophysiology. 68 (1): 213–32. PMID 1325546. Unknown parameter |month= ignored (help)
  10. ^ Sayer RJ, Brown AM, Schwindt PC, Crill WE. "Calcium currents in acutely isolated human neocortical neurons." Journal of Neurophysiology. 1993 May;69(5):1596-606. PMID 8389832 Fulltext
  11. ^ Todorovic SM, Lingle CJ (1998). "Pharmacological properties of T-type Ca2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents". Journal of Neurophysiology. 79 (1): 240–52. PMID 9425195.
  12. ^ Leresche N, Parri HR, Erdemli G, Guyon A, Turner JP, Williams SR, Asprodini E, Crunelli V (1998). "On the action of the anti-absence drug ethosuximide in the rat and cat thalamus". Journal of Neuroscience. 18 (13): 4842–53. PMID 9634550.CS1 maint: multiple names: authors list (link)
  13. ^ Gomora JC, Daud AN, Weiergraber M, Perez-Reyes E (2001). "Block of cloned human T-type calcium channels by succinimide antiepileptic drugs". Molecular Pharmacology. 60 (5): 1121–32. PMID 11641441.CS1 maint: multiple names: authors list (link)
  14. ^ Bourgeois, BF (1988). "Combination of valproate and ethosuximide: antiepileptic and neurotoxic interaction". The Journal of Pharmacology and Experimental Therapeutics. 247 (3): 1128–32. PMID 3144596. Unknown parameter |month= ignored (help)