بانية العظم
| بانية العظام Osteoblast | |
|---|---|
 Osteoblasts (blue) rimming a bony spicule (pink - on diagonal of image). In this routinely fixed and decalcified (bone mineral removed) tissue, the osteoblasts have retracted and are separated from each other and from their underlying matrix. In living bone, the cells are linked by tight junctions and gap junctions, and integrated with underlying osteocytes and matrix H&E stain. | |
| Details | |
| Identifiers | |
| اليونانية | osteoblast |
| MeSH | D010006 |
| TH | TH {{{2}}}.html HH2.00.03.7.00002 .{{{2}}}.{{{3}}} |
| FMA | 66780 |
| المصطلحات التشريحية | |
الخلية بانية العظم إنگليزية: Osteoblast هي خلية ذات نواة واحدة تُصنّع العظم.
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تمعدن العظم
At least one more regulated transport process is involved. The stoichiometry of bone mineral basically is that of hydroxyapatite precipitating from phosphate, calcium, and water at a slightly alkaline pH:[1]
6 HPO42− + 2 H2O + 10 Ca2+ ⇌ Ca10(PO4)6(OH)2 + 8 H+
التشكل والتبقع النسيجي
Hematoxylin and eosin staining (H&E) shows that the cytoplasm of active osteoblasts is slightly basophilic due to the substantial presence of rough endoplasmic reticulum. The active osteoblast produces substantial collagen type I. About 10% of the bone matrix is collagen with the balance mineral.[2] The osteoblast's nucleus is spherical and large. An active osteoblast is characterized morphologically by a prominent Golgi apparatus that appears histologically as a clear zone adjacent to the nucleus. The products of the cell are mostly for transport into the osteoid, the non-mineralized matrix. Active osteoblasts can be labeled by antibodies to Type-I collagen, or using naphthol phosphate and the diazonium dye fast blue to demonstrate alkaline phosphatase enzyme activity directly.
Osteoblast (Wright Giemsa stain, 100x)
Light micrograph of decalcified (a process that removes the mineral) cancellous bone displaying osteoblasts actively synthesizing osteoid, containing two osteocytes.
Light micrograph of undecalcified tissue displaying osteoblasts actively synthesizing osteoid (center).
Light micrograph of undecalcified tissue displaying osteoblasts actively synthesizing rudimentary bone tissue (center).
Osteoblasts lining bone (H&E stain).
انظر أيضا
مراجع
- ^ Neuman, William F.; Neuman, Margaret W. (1958). The Chemical Dynamics of Bone Mineral. Chicago: The University of Chicago Press. ISBN 0-226-57512-8.
- ^ Neuman, William F.; Neuman, Margaret W. (1958). The Chemical Dynamics of Bone Mineral. Chicago: The University of Chicago Press. ISBN 0-226-57512-8.
للاستزادة
- William F. Neuman and Margaret W. Neuman. (1958). The Chemical Dynamics of Bone Mineral. Chicago: The University of Chicago Press. ISBN 0-226-57512-8.
- Netter, Frank H. (1987). Musculoskeletal system: anatomy, physiology, and metabolic disorders. Summit, New Jersey: Ciba-Geigy Corporation ISBN 0-914168-88-6.