جون سلستن

جون سلستن
John E. Sulston
Sulston in 2008
Sulston in 2008
CH FRS
ولدَ فيJohn Edward Sulston
(1942-03-27)27 مارس 1942[1]
Fulmer, Buckinghamshire, England
توفي في6 مارس 2018(2018-03-06) (عن عمر 75 عاماً)
الجنسيةBritain
القوميةEnglish
مجال البحث
المؤسسات
خريجUniversity of Cambridge (BA, PhD)
مشرف الدكتوراهColin Reese[2][3]
اشتهر بسببGenome sequencing of Caenorhabditis elegans and humans[4][5][6][7]
Sulston score[8]
استموات
التأثيرات
الجوائز
EBI ومعامل سلستن في معهد سانگر.

جون إدوارد سلستن John E. Sulston، (و. 27 مارس 1942[13][14])، هو عالم أحياء بريطاني. حصل على جائزة نوبل في الطب سنة 2002 for his work on the cell lineage and genome of the worm Caenorhabditis elegans in 2002 with his colleagues سيدني برنر و Robert Horvitz. He was a leader in human genome research and Chair of the Institute for Science, Ethics and Innovation at the University of Manchester.[15][16][17] Sulston was in favour of science in the public interest, such as free public access of scientific information and against the patenting of genes and the privatisation of genetic technologies.[18]

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النشأة

Sulston was born in Fulmer, Buckinghamshire, England[19] to Arthur Edward Aubrey Sulston and Josephine Muriel Frearson, née Blocksidge.[1][20] His father was an Anglican priest and administrator of the Society for the Propagation of the Gospel. His mother quit her job as an English teacher at Watford Grammar School, to care for him and his sister Madeleine.[21] and home-tutored them until he was five. At age five he entered the local preparatory school, York House School, where he soon developed an aversion to games. He developed an early interest in science, having fun with dissecting animals and sectioning plants to observe their structure and function.[3] Sulston won a scholarship to Merchant Taylors' School, Northwood[1] and then to Pembroke College, Cambridge graduating in 1963 with a Bachelor of Arts[1] degree in Natural Sciences (Chemistry). He joined the Department of Chemistry, University of Cambridge, after being interviewed by Alexander Todd[3][22] and was awarded his PhD in 1966 for research in nucleotide chemistry.[2]


السيرة

لعب سلستن دوراً مركزياً في مشروعي تسلسل جينوم الدودة Caenorhabditis elegans [5] والجينوم البشري[23]. He had argued successfully for the sequencing of C. elegans to show that large-scale genome sequencing projects were feasible. As sequencing of the worm genome proceeded, the project to sequence the human genome began. At this point he was made director of the newly established Sanger Centre (named after فرد سانگر and now the وقف ولكم معهد سانگر)، الكائن في كمبردج‌شاير، إنگلترة.

وقد قام سلستن بدفع الكفالة المطلوبة من جوليان أسانج، حسب مارك ستيفنز، محامي جوليان. [1].

انظر أيضا

وصلات خارجية

سيرة ذاتية

المنشورات

أخبار ومعلومات

مناصب منظمات غير ربحية
سبقه
مدير معهد سانگر
1993–2000
تبعه
ألان برادلي

قالب:FRS 1986 قالب:Wellcome Trust

  1. ^ أ ب ت ث قالب:Who's Who (يتطلب اشتراك)
  2. ^ أ ب Sulston, John Edward (1966). Aspects of oligoribonucleotide synthesis. repository.cam.ac.uk (PhD thesis). University of Cambridge. doi:10.17863/CAM.16307. قالب:EThOS. قالب:Free access
  3. ^ أ ب ت ث John E. Sulston on Nobelprize.org, accessed 11 أكتوبر 2020
  4. ^ Wilson, R.; Ainscough, R.; Anderson, K.; Baynes, C.; Berks, M.; Bonfield, J.; Burton, J.; Connell, M.; Copsey, T.; Cooper, J.; Coulson, A.; Craxton, M.; Dear, S.; Du, Z.; Durbin, R.; Favello, A.; Fraser, A.; Fulton, L.; Gardner, A.; Green, P.; Hawkins, T.; Hillier, L.; Jier, M.; Johnston, L.; Jones, M.; Kershaw, J.; Kirsten, J.; Laisster, N.; Latreille, P.; Lightning, J. (1994). "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. Elegans". Nature. 368 (6466): 32–38. Bibcode:1994Natur.368...32W. doi:10.1038/368032a0. PMID 7906398. S2CID 21450455.
  5. ^ أ ب Sulston, J.; Brenner, S. (1974). "The DNA of Caenorhabditis elegans". Genetics. 77 (1): 95–104. doi:10.1093/genetics/77.1.95. PMC 1213121. PMID 4858229.
  6. ^ Sulston, J. E.; Schierenberg, E.; White, J. G.; Thomson, J. N. (1983). "The embryonic cell lineage of the nematode Caenorhabditis elegans". Developmental Biology. 100 (1): 64–119. doi:10.1016/0012-1606(83)90201-4. PMID 6684600.
  7. ^ Sulston, J. E.; Horvitz, H. R. (1977). "Post-embryonic cell lineages of the nematode, Caenorhabditis elegans". Developmental Biology. 56 (1): 110–156. doi:10.1016/0012-1606(77)90158-0. PMID 838129.
  8. ^ Sulston, J.; Mallett, F.; Staden, R.; Durbin, R.; Horsnell, T.; Coulson, A. (1988). "Software for genome mapping by fingerprinting techniques". Computer Applications in the Biosciences. 4 (1): 125–132. doi:10.1093/bioinformatics/4.1.125. PMID 2838135.
  9. ^ Dunitz, J. D.; Joyce, G. F. (2013). "Leslie Eleazer Orgel. 12 January 1927 -- 27 October 2007". Biographical Memoirs of Fellows of the Royal Society. 59: 277–289. doi:10.1098/rsbm.2013.0002. S2CID 72244996.
  10. ^ خطأ استشهاد: وسم <ref> غير صحيح؛ لا نص تم توفيره للمراجع المسماة membo
  11. ^ خطأ استشهاد: وسم <ref> غير صحيح؛ لا نص تم توفيره للمراجع المسماة frs
  12. ^ خطأ استشهاد: وسم <ref> غير صحيح؛ لا نص تم توفيره للمراجع المسماة beadle
  13. ^ Kolata, Gina (15 March 2018). "John E. Sulston, 75, Dies; Found Clues to Genes in a Worm". The New York Times.
  14. ^ Waterston, Robert H.; Ferry, Georgina (2019). "Sir John Edward Sulston CH. 27 March 1942 – 6 March 2018". Biographical Memoirs of Fellows of the Royal Society. 67: 421–447. doi:10.1098/rsbm.2019.0014. S2CID 186212646.
  15. ^ "Professor Sir John Sulston - personal details". The University of Manchester. Archived from the original on 11 October 2009. Retrieved 6 November 2014.
  16. ^ Gitschier, Jane (2006). "Knight in Common Armor: An Interview with Sir John Sulston". PLOS Genetics. 2 (12): e225. doi:10.1371/journal.pgen.0020225. PMC 1756915. PMID 17196043. قالب:Open access
  17. ^ Sulston, J. (2002). "A conversation with John Sulston". The Yale Journal of Biology and Medicine. 75 (5–6): 299–306. PMC 2588810. PMID 14580111.
  18. ^ Ivan Oransky, Adam Marcus John Sulston. obituary 7 April 2018, The Lancet
  19. ^ Ferry, Georgina (11 March 2018). "Sir John Sulston obituary". The Guardian.
  20. ^ "John E. Sulston". NNDB. Soylent Communications. Retrieved 21 April 2014.
  21. ^ "John Sulston Biography Nobel Prize in Medicine". American Academy of Achievement. Archived from the original on 23 April 2014. Retrieved 21 April 2014.
  22. ^ Brown, D. M.; Kornberg, H. (2000). "Alexander Robertus Todd, O.M., Baron Todd of Trumpington. 2 October 1907 -- 10 January 1997: Elected F.R.S. 1942". Biographical Memoirs of Fellows of the Royal Society. 46: 515–532. doi:10.1098/rsbm.1999.0099. S2CID 73076704.
  23. ^ PMID 11237011 (PubMed)
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