بيتا-كربولين

β-Carboline
الأسماء
	اسم أيوپاك المفضل 9H-Pyrido[3,4-b]indole
	أسماء أخرى Norharmane; Norharman; Carbazoline; 2-Azacarbazole; 2,9-Diazafluorene;
المُعرِّفات
رقم CAS
3D model (JSmol)	Interactive image;
مرجع بايلستاين	128414
ChEBI	CHEBI:109895 ;
ChEMBL	ChEMBL275224 ;
ChemSpider	58486 ;
رقم EC	205-959-0;
IUPHAR/BPS	8222;
KEGG	C20157;
عناوين مواضيع طبية MeSH	{{{value}}}
PubChem CID	64961;
UNII	94HMA1I78O ;
	InChI InChI=1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H Key: AIFRHYZBTHREPW-UHFFFAOYSA-N ; InChI=1/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H Key: AIFRHYZBTHREPW-UHFFFAOYAG;
	SMILES c1ccc3c(c1)[nH]c2cnccc23;
الخصائص
الصيغة الجزيئية	C11H8N2
كتلة مولية	168.20 g/mol
	ما لم يُذكر غير ذلك، البيانات المعطاة للمواد في حالاتهم العيارية (عند 25 °س [77 °ف]، 100 kPa).
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	مراجع الجدول

β-Carboline, also known as norharman, norharmane, or 9H-pyrido[3,4-b]indole, is a tricyclic chemical compound and alkaloid.^[1] It is the parent structure of the substituted β-carbolines, a large group of alkaloids and synthetic compounds.^[1] β-Carboline may be thought of as a cyclized tryptamine.^[1] The compound has been found to possess a variety of pharmacological activities, including DNA mutagenic effects, imidazoline receptor interactions, serotonin reuptake inhibition, monoamine oxidase inhibition, cytochrome P450 enzyme inhibition, and inhibition of other enzymes, among others.^[1]

β-Carboline shows weak affinity for the serotonin 5-HT_2B and 5-HT_2C receptors (K_i = 738 nM and 2,522 nM, respectively), but not for the serotonin 5-HT_2A receptor (K_i = >10,000 nM).^[2]

انظر أيضاً

^ ^أ ^ب ^ت ^ث Cao R, Peng W, Wang Z, Xu A (2007). "beta-Carboline alkaloids: biochemical and pharmacological functions". Curr Med Chem. 14 (4): 479–500. doi:10.2174/092986707779940998. PMID 17305548.
^ Foley, Caroline A.; Al-Issa, Yazan A.; Hiller, Kathryn P.; Mulcahy, Seann P. (30 June 2019). "Synthesis and Structure–Activity Relationships of 1-Aryl-β-carbolines as Affinity Probes for the 5-Hydroxytryptamine Receptor". ACS Omega. 4 (6): 9807–9812. doi:10.1021/acsomega.9b01111. ISSN 2470-1343.