گليمپيريد

گليمپيريد

البيانات السريرية
رمز ATC	A10BB12 (WHO)
بيانات الحركية الدوائية
ارتباط الپروتين	>99.5%
المعرفات
IUPAC name 3-ethyl-N,N-bis (3-ethyl-4-methyl-2-oxo-5H-pyrrol-2-yl)- 4-methyl-2-oxo-5H-pyrrole-1- carboxamide
رقم CAS	93479-97-1
PubChem CID	3476
DrugBank	APRD00381
CompTox Dashboard (EPA)	DTXSID5040675
ECHA InfoCard	100.170.771
Chemical and physical data
التركيب	C24H34N4O5S
الكتلة المولية	490.617 g/mol

گليمپيريد Glimepiride هو سلفون يوريا sulfonylurea ودواء مضاد للسكري مفعوله متوسط إلى طويل المدى. ويُسوّق باسم أماريل Amaryl® من قِبل سانوفي أڤنتيس Sanofi-Aventis.

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 الوصف

گليمپيريد هو أول الجيل الثالث من مجموعة السلفونيل يوريا وهو ممتد المفعول .

 آلية العمل

Glimepiride distinctly lower the blood glucose level by both defects of NIDDM, by stimulating pancreatic beta cells to produce more insulin and induced increased activity of peripheral insulin intra cellular receptor.

 فارماكولوجيا إكلينيكية

With Glimepiride GI absorption is complete with no interference of meals. Significant absorption of glimepiride was seen within one hour, and distributed through out the body, bound to the plasma protein to an extended of 99.5% and it is metabolised by oxidative biotransformation and 60% is excreted in the urine, and remaining is excreted in the feces.

 Dosage

There is no fixed dosage regimen for the management of diabetes mellitus with GLI, in general the dosage of GLI should be lowest which is sufficient to achieve the desired metabolic control. Starting dose : 1-2mg OD Maintenance :1-4mg OD Maximum recommended dose : 8mg OD

 Contra-Indication

Hypersensitivity to glimepiride other sulphonyl urea.

 تفاعلات الدواء

With NSAIDs like Salicylates, Sulphoamides, Chlorampenicol, coumarin and probencid may potentiate the hypoglycemic action of glimepride. Thiazides, other diuretic, phothiazides, thyroid products, oral contraceptives, phenytoin tend to produce hyperglycemia.

 محاذير خاصة

In the initial weeks of treatment the risk of hypoglycemia, may be increased and necessities especially careful monitoring.

 تأثير عكسي

GI disturbance, rarely thrombopenia , leucopenia, haemolytic anaemia, occasionally allergic.

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